Journal: Frontiers in Endocrinology
Article Title: First in class monoclonal antibody potentiating human follicle stimulating hormone activity improves spermatogenesis in azoospermic rodent models
doi: 10.3389/fendo.2025.1668945
Figure Lengend Snippet: Effect of IGX12 in hpg mice. Testicular sperm count (A) , haploid/tetraploid cell ratio in testes (B) , sperm count in epididymides (C) , haploid cell count in epididymides (D) and intratesticular testosterone level (E) after treatment with either rhFSH and then hMG, or rhFSH+IGX12 and then hMG+IGX12. n=8 mice per group. Results were expressed as median with 10–90 percentile (*p<0.05 and **p<0.01) ns stands for non-significant.
Article Snippet: After testicular sperm reserve assessment, the sample is used to quantify the intratesticular testosterone levels using a commercially available kit from Cayman (Interchim, Montluçon, France).
Techniques: Cell Counting